Streptococcal Fibrinolysis: a Proteolytic Reaction Due to a Serum Enzyme Activated by Streptococcal Fibrinolysin

A Proteolytic Enzyme of Serum: Characterization, Activation, and Reaction with Inhibitors

1. Fibrinolysin-activated lysin factor and chloroform-activated serum protease of serum and plasma are one and the same enzyme, differing only in their mode of activation. 2. The enzyme as it normally occurs in serum or plasma is not inactive because of combination with serum inhibitor. It is present as an inactive precursor or zymogen and may be activated from this state by streptococcal fibri...

Studies on a Proteolytic Enzyme in Human Plasma

A fraction of globulin was prepared from human plasma which was deficient in prothrombin, thrombin, fibrinogen, plasma thromboplastin, and accelerator globulin. The preparation of globulin contained considerable potential proteolytic activity which could be activated by streptococcal fibrinolysin. This fraction of globulin accelerated the clotting of normal platelet-deficient plasma. However, t...

Treatment of clotted hemothorax with fibrinolysin.

The lysis and aspiration of a clotted hemothorax by means of an effective enzymatic agent is highly desirable. Various enzymes have been used for this purpose but alt have certain disadvantages. Trypsin has an irritative effect of pleural pain on injection and often shows a toxic reaction due to the enzyme or breakdown of protein products.’ The inhibitor (antitrypsin) normally present in the se...

A Proteolytic Enzyme Produced by Group a Streptococci with Special Reference to Its Effect on the Type-specific M Antigen

1. Group A streptococci sometimes produce in broth culture an extracellular proteolytic enzyme. 2. Under suitable cultural conditions the enzyme has been demonstrated in representative cultures of most of the Griffith types. Its production by a given strain may be suppressed by serial passage through mice and the variant so produced has been found to maintain this change in character on subcult...

Studies of streptococcal fibrinolysis; a quantitative method for the estimation of serum antifibrinolysin.